The incident happened at about 1:24 a.m., on Route 50 at the intersection with Montague Street.
Police say the man was trying to cross Route 50 when he was struck by an eastbound vehicle. He was thrown into the westbound lanes, where he was again struck by a second vehicle.
The first responding police officers arrived on scene and determined that the man was dead. Route 50 was shut down for several hours while police investigated the incident.
Charges are not expected to be filed against the drivers. The man has yet to be identified, but police say he was a white male and believed to be in his 30s.